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Procellax DG2

$63.88

Out of Stock

SKU: 249

Product Info

What It Does:
  • Breaks down gluten in wheat, barley and rye, and casein in dairy products.
  • DPP-IV proteolytic-enzyme complex.
  • Relieves indigestion, gas, bloating, constipation and diarrhoea.

Benefits of This Product:

Breaks down hard-to-digest proteins such as gluten and casein

Improves digestion of carbohydrates

Stays active in a wide range of pH

ProCellax DG2 utilizes powerful protease enzymes to support the digestion of proteins such as gluten and casein.

ProCellax DG2 allows gluten and casein proteins to be properly broken down. It also relieves gas, bloating and constipation caused by improper digestion.

This powerful enzyme supplement aids digestion of gluten-containing cereals, including wheat, casein-containing dairy products and other high-protein foods.

ProCellax DG2 also assists in fat and oil digestion with the enzyme lipase. It contains eight specific enzymes for complete sugar, carbohydrate and polysaccharide digestion.

Comparison

Comparison of ProCellax® Enzymes’ Digestive Enzyme Blends

ProCellax® DG1 ProCellax® DG2
Protein Digestion
Proteases
Serrapeptase
DPP-IV √√
Bromelain
Papain
Carbohydrate Digestion
Amylase √√
Glucoamylase
Lactase
Maltase
Invertase
Cellulase
HemiSEB®
Alpha-Galactosidase
Fat Digestion
Lipase

When choosing a digestive enzyme supplement, it is important to know the specific benefits of the product and how they meet your needs. Each of ProCellax® Enzymes’ digestive enzyme blends is specially designed to suit a variety of digestion concerns and issues.

ProCellax® DG1 is an all-encompassing digestive enzyme blend. Simply put – it has a little bit of everything. By including a variety of enzymes capable of digesting all food types, ProCellax® DG1 is very versatile and can be taken with any meal to aid in the digestive process.

ProCellax® DG2 is specially formulated to assist with the digestion of gluten-rich foods. Products are typically characterized by their gluten contents (for example, bread and pasta are also carbohydrate heavy). To address this, additional carbohydrate-digesting enzymes are included in Gluten Relief to complement the powerful DPP-IV activity.

Research

Research

The enzyme ingredients found in ProCellax DG2 demonstrate a number of benefits when applied to conditions related to impaired gluten digestion.

The proteolytic enzyme dipeptidyl dipeptidase IV (DPP IV) is contained within the cells that line the villi of the small intestine.

Celiac disease research has included the investigation of the role of DPP IV in the digestion of the portion of the protein found in gluten that is recognized as an “offender” by the immune system, also called an epitope.

The particular epitopes of concern in gliadin are rich in the amino acid proline. Studies show that endopeptidases, or enzymes that break protein bonds from within the molecule rather than at the ends, that are normally released by the pancreas do not effectively digest the epitopes. This suggests that DPP IV digestion in the small intestine is critical. Research has also found that DPP IV activity in patients with celiac disease is low and that they may not have the capacity to digest the protein after a gluten-rich meal, contributing to the development of the disease.

Autism research has included the investigation of the role of DPP IV in the digestion of the epitopes that can trigger an autoimmune response. These epitopes have also demonstrated the ability to pass, or permeate, through the lining of the intestines and travel through the blood to the brain where they interfere with normal cognitive processing.

At this time, clinical studies relevant to gluten and casein functions in autism are limited to the removal of these factors from the diet rather than DPP IV supplementation to break them down. Proper maintenance of a gluten-free/casein-free diet is difficult, however, because many everyday foods and items are hidden sources.

Researchers looked at supplementing with DPP IV, as well as other prolyl (proline-specific) endopeptidases in celiac disease. They found that supplementing with DPP IV can compensate for the slow protein digestion, and that supplementing with additional proteases like prolyl endopeptidase (PEP), in combination with DPP IV, may be useful in reducing or even eliminating the inflammatory response related to gluten.

There is growing evidence that suggests that taking a combination of proteases for gluten digestion is more beneficial than a single enzyme. In one study, activity of X-prolyl dipeptidyl aminopeptidase (X-PDAP), a non-specific DPP enzyme, was measured alone and in combination with another enzyme, non-specific monoanimopeptidase (AP). When AP was combined with subtilisin (a serine-specific endopeptidase), gluten digestion was measured at 47%. Upon adding X-PDAP, activity increased to 64%, suggesting a synergism in breaking down proteins when these enzymes are taken as a complex.7 Another study looked at the possibilities of a combination enzyme therapy in treating celiac disease. Researchers concluded that by combining 2 enzymes with normal digestive activity it should be possible to increase the safe threshold of ingested gluten, reducing the need for a highly restricted diet for celiac patients.

Ingredients

Enzyme Activity in ProCellax DG2 (Proprietary Blend):
Enzymes How It Works
Dipeptidyl Peptidase IV (DPP-IV)SEB-Pro GR Breaks down carbohydrates, more specifically starch, into smaller dextrins and sugars; produced naturally by humans, microorganisms and plants
Amylase I, II & Glucoamylase Break down carbohydrates, more specifically starch, into smaller dextrins and sugars; produced naturally by humans, microorganisms and plants.
Cellulase Digests cellulose, a complex polysaccharide found in all plant material, including plant fiber.
Hemicellulase and Xylanase(HemiSEB cellulose) Break down carbohydrates such as fiber and other plant polysaccharides such as hemicellulose, a major component of plant cell walls.
Alpha-Galactosidase Breaks down complex carbohydrates such as raffinose and stachyose commonly contained in legumes, cruciferous vegetables and grains.
Lactase Breaks down lactose, the difficult to digest disaccharide found in milk, into simple sugars for easier absorption.
Lipase Catalyzes the break-down of fats into essential fatty acids that are needed for healthy tissues and cells.

1. Kozakova H, Steepankova R, Kolinska J, et al. Brush border enzyme activities in the small intestine after long-term gliadin feeding in animal models of human coeliac disease. Folia Microbiol (Praha). 1998; 43(5):497-500.

2. Koch S, Anthonsen D, Skovbjerg H, Sjöström H. On the role of dipeptidyl peptidase IV in the digestion of an immunodominant epitope in celiac disease. Adv Exp Med Biol. 2003; 524:181-7.

3. Detel D, Persic M, Varljen J. Serum and Intestinal Dipeptidyl Peptidase IV (DPP IV/CD26) Activity in Children With Celiac Disease. J Ped Gast Nutr. 2007; 45(1):65-70.

4. Hemmins WA. The entry into the brain of large molecules derived from dietary protein. Proc Roy Soc London Ser B. 1978; 200:175-192.

5. Marti T, Molberg O, Li Q, et al. Prolyl Endopeptidase-Mediated Destruction of T Cell Epitopes in Whole Gluten: Chemical and Immunological Characterization. J Pharmacol Exp Ther. 2005; 312(1):19-26.

6. Hausch F, Shan L, Santiago NA, et al. Intestinal digestive resistance of immunodominant gliadin peptides. Am J Physiol Gastrointest Liver Physiol. 2002; 283(4):G996-G1003.

7. Resta-Lenert S, Barrett KE. Live probiotics prtect intestinal epithelial cells from the effects of infection with enterovasasive Escherichia coli (EIEC). Gut. 2003; 52:988-97.

8. De Palma G, Cinova J, Stepankova R, et al. Pivotal Advance: Bifidobacteria and Gram-negative bacteria differentially influence immune responses in the proinflammatory milieu of celiac disease. J Leukocyte Biol. 2010; 87(5):765-78.

FAQ

What is gluten? Gluten is a protein that is present in wheat, barley and rye products. Gluten is often used in manufacturing food because it provides structural stability and elasticity to the product. Americans are increasingly reporting intolerance to gluten, manifesting as symptoms of gastrointestinal disruption in response to ingestion of offending foods. However, it is difficult to eliminate gluten completely from the diet, as there are several hidden sources.

Why is it important to take Gluten Relief with food? Since Gluten Relief aids in digestion, it is contraindicated to use the enzyme without eating. Although it is not harmful to take Gluten Relief on an empty stomach, it is simply a waste of money. If you take digestive enzymes too soon before a meal, you risk the enzyme becoming inactive. The food and enzyme must be in the stomach together for proper results.

Are there any side effects involved with Gluten Relief? Side effects with Gluten Relief are rare, but not impossible. Mild cramping may occur, as the intestinal lining begins to cleanse. Other rare, but reported side effects include minor gastrointestinal disturbances, like bloating or gas. Starting off at a low dose can minimize any possible side effects. Side effects should clear with regular use, after a tolerance is established.

Can I take Gluten relief with other systemic or digestive enzymes? Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they should not be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes, and thus should be taken as directed for best results.

Can I open the capsule and pour it onto my food instead of swallowing the capsule? If you find that you have trouble swallowing the capsules, pouring its contents onto food is definitely an option. You may also open the capsule into a glass of water, being sure to drink the entire glass. If you choose to take the enzymes this way, it is best to consume the entire content as soon as possible to ensure you are receiving the full benefits within your body (rather than on your plate).